Where is abnormal IgG production described as occurring in the context of RA?

Where is abnormal IgG production described as occurring in the context of RA?

• A. In the liver
• B. In the spleen
• C. In the joint capsules
• D. In bone marrow

Answer: (C)

In rheumatoid arthritis, antibody-producing cells infiltrate the joint itself. The synovial membrane becomes populated with B cells and plasma cells that actively secrete IgG directly within the inflamed joint. This local production contributes to immune complex formation and ongoing inflammation in the joint space, driving tissue damage and pannus formation. While IgG can be produced systemically in organs like the liver, spleen, and bone marrow, the abnormal IgG production described in RA is specifically localized to the joint capsules (the synovium).

In rheumatoid arthritis, antibody-producing cells infiltrate the joint itself. The synovial membrane becomes populated with B cells and plasma cells that actively secrete IgG directly within the inflamed joint. This local production contributes to immune complex formation and ongoing inflammation in the joint space, driving tissue damage and pannus formation. While IgG can be produced systemically in organs like the liver, spleen, and bone marrow, the abnormal IgG production described in RA is specifically localized to the joint capsules (the synovium).