Which acronym represents the pharmacokinetic steps of drug disposition?

Which acronym represents the pharmacokinetic steps of drug disposition?

• A. ADMEG
• B. LADME
• C. PQRST
• D. CADD

Answer: (B)

The key idea is the sequence of processes that determine how a drug moves through and is handled by the body. This sequence is captured by the LADME series: Liberation, Absorption, Distribution, Metabolism, and Excretion (Elimination). Liberation refers to the drug being released from its dosage form, which sets the stage for how much drug can enter the body. Absorption is the entry of the drug into the bloodstream. Distribution describes how the drug spreads to tissues and organs. Metabolism is the body's chemical alteration of the drug, often in the liver. Excretion (Elimination) is how the drug and its metabolites are removed from the body, via kidneys, bile, lungs, etc. Among the options, this acronym uniquely includes both Liberation and Excretion, reflecting the full disposition process. Other choices either use nonstandard letters or omit steps such as liberation or elimination, so they don’t accurately represent the complete pharmacokinetic sequence.

The key idea is the sequence of processes that determine how a drug moves through and is handled by the body. This sequence is captured by the LADME series: Liberation, Absorption, Distribution, Metabolism, and Excretion (Elimination). Liberation refers to the drug being released from its dosage form, which sets the stage for how much drug can enter the body. Absorption is the entry of the drug into the bloodstream. Distribution describes how the drug spreads to tissues and organs. Metabolism is the body's chemical alteration of the drug, often in the liver. Excretion (Elimination) is how the drug and its metabolites are removed from the body, via kidneys, bile, lungs, etc. Among the options, this acronym uniquely includes both Liberation and Excretion, reflecting the full disposition process. Other choices either use nonstandard letters or omit steps such as liberation or elimination, so they don’t accurately represent the complete pharmacokinetic sequence.